Presenter: Dylan Guan, MD/PhD Student, University of Calgary (left)
Learning Objectives:
Identify which vascular risk factors are linked to dementia
Review the evidence surrounding each vascular risk factor linked to dementia
Understand the methods used to calculate and interpret population attributable fractions for each vascular risk factor
Take a closer read: Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission - The Lancet
Dylan Guan is an MD/PhD student at the University of Calgary. He holds an Honours Bachelor of Science from the University of Toronto, with a major in Neuroscience and minors in Physiology and Psychology. Dylan has been recognized with numerous prestigious awards, including the Vanier Canada Graduate Scholarship, Izaak Walton Killam Memorial Scholarship, Alzheimer’s Society Research Program Doctoral Award, Hotchkiss Brain Institute Harley Hotchkiss Doctoral Scholarship in Neuroscience, and Vascular Training Platform (VAST) Doctoral Award. He has published >15 peer-reviewed journal articles, presented >35 conference abstracts at various national and international conferences, and was an invited speaker for events hosted by the Alzheimer Society of Canada, Alzheimer’s Association International Society to Advance Alzheimer’s Research and Treatment (ISTAART), Canadian Consortium on Neurodegeneration in Aging (CCNA), and VAST. Dylan’s research focuses on identifying and better understanding signs of Alzheimer’s disease prior to the onset of dementia.
Recording
Presenter: Sotaro Hirai, PhD Candidate in Neuroscience, University of Calgary (right)
Learning Objectives:
Understand the method used to assess cerebral blood flow changes
Understand one mechanism by which cerebral blood flow control is impaired in Alzheimer’s disease and how it may be rescue
Take a closer read: Inhibiting Ca2+ channels in Alzheimer’s disease model mice relaxes pericytes, improves cerebral blood flow and reduces immune cell stalling and hypoxia
Sotaro is a PhD candidate at the University of Calgary, co-supervised by Dr.Minh Dang Nguyen and Dr.Grant Gordon. He completed his Honours Bachelor in Science at the University of Toronto with majors in Computational Biology and Immunology, and a minor in Computer Science. His current research delves into how the dysfunction in brain endothelial cells may contribute to Alzheimer’s disease pathology by using microscopy and molecular biology techniques.